183 papers
Molecular biology explores the tiny machinery inside living cells, revealing how genetic instructions are read, copied, and turned into the proteins that keep us alive. This field acts as a bridge between the static code of DNA and the dynamic processes that drive growth, disease, and life itself, offering insights into everything from cellular repair to the development of new medicines.
On Gist.Science, we track every new preprint uploaded to bioRxiv in this category to make these complex discoveries accessible to everyone. Our team processes each submission to provide both clear, plain-language explanations and detailed technical summaries, ensuring you can grasp the core findings without getting lost in dense academic jargon.
Below are the latest molecular biology papers freshly processed from bioRxiv, ready for you to explore and understand.
This paper presents a safer, high-sensitivity fluorescent in situ hybridization (FISH) protocol for cryosections that replaces toxic reagents with low-toxicity alternatives while enabling multiplexed mRNA detection, preserving tissue integrity without proteolytic enzymes, and allowing simultaneous immunostaining.
This study introduces a targeted 3'-end RNA sequencing method (3TRS) that reveals how long, pure, and somatically unstable CAG repeats in Huntington's disease drive the expression of the pathogenic HTT1a isoform through cryptic polyadenylation, offering a robust framework for investigating disease mechanisms and therapeutic strategies.
This study identifies RSK1 as a central, GSK3β-independent mediator that drives Tau phosphorylation in response to both HIV and cocaine exposure, revealing a convergent signaling mechanism that contributes to neurocognitive dysfunction and suggesting RSK1 inhibition as a potential therapeutic strategy for Tau-associated pathologies.
Based on 15 years of breeding data from southern Sweden, this study reveals that avian malaria prevalence in blue tits is significantly shaped by host age, sex, and local habitat, with infection rates increasing over time and accumulating in older birds, thereby underscoring the critical value of long-term research for understanding host-parasite dynamics.
This study characterizes the functional impacts of specific RNase R mutations on RNA binding and degradation while providing a detailed, cost-effective protocol for purifying high-quality recombinant RNase R in E. coli using standard FPLC systems to facilitate circRNA research and therapeutic development.
This study demonstrates that frataxin depletion in dorsal root ganglia sensory neurons causes a reduction in soma size driven by mitochondrial dysfunction-induced AMPK hyperactivation and mTOR suppression, a phenotype that can be rescued by restoring frataxin, inhibiting AMPK, or treating with alpha-lipoic acid.
This study employs yeast two-hybrid screening to map a comprehensive interactome of the yeast SET1C complex, revealing novel connections to RNA biogenesis and nuclear transport while demonstrating that Set1 methylates the AT-hook domain of the chromatin remodeler Snf2, thereby uncovering a new interplay between lysine and arginine methylation.
This study demonstrates that specific combinations of evolutionarily conserved rattlesnake serum metalloproteinase inhibitors (FETUAs) can fully neutralize the lethal effects of diverse viper venoms with significantly greater potency than current commercial antivenoms, offering a promising new therapeutic strategy for snakebite treatment.
This study reveals that the Farnesoid X receptor (FXR) and BET signaling pathways cooperatively protect pancreatic {beta} cells from inflammation-induced dysfunction and loss of identity in diabetes by forming a direct protein-protein interaction, suggesting that combined FXR activation and BET inhibition represents a promising therapeutic strategy to preserve {beta} cell function in both type 1 and type 2 diabetes.
This study reveals that the TREX2 complex functions as a modular system where the scaffold protein PCID2 assembles into distinct, evolutionarily conserved subcomplexes with GANP, LENG8, or SAC3D1 to direct specific RNA processing and export pathways to different cellular compartments.